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Example coding DNA reference sequences - alternatively spliced exons |
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Since references to WWW-sites are not yet acknowledged as citations, please mention den Dunnen JT and Antonarakis SE (2000). Hum.Mutat. 15:7-12 when referring to these pages.
Detailed expression analysis of this fictive gene showed that a minor fraction of the transcripts (<5%) contained an alternatively spliced exon located entirely inside intron 53. Based on a coding DNA reference sequence, numbering of these differentially spliced nucleotides is straightforward, i.e. as for the intronic nucleotides c.9660+290 to c.9660+319. The encoded amino acids can best be numbered p.Pro3220+1 to p.Gln3220+10; this number clearly indicates their position in relation to the other amino acids with the '+' number indicating a location in an intron (see below).
. . . . . . | TATGAAGAGAAGATGGCTCGCAGATTGCTAGGACCACAGAATGCAGCTGCTGTGTTTCAA | 9660 Y E E K M A R R L L G P Q N A A A V F Q | 3220 . . . . . . gtacgtatggcatgtttttatttcccgtacgaggtaagcctccaaagaccttgagaattc 9660+60 . . . . . . gtgaagtgtaattagcattacaacagggccctggaagctgtggacctaatgctcttcctg 9660+120 . . . . . . tgataaatcatttttgcatttatgacttgaaaaatattttgataagctaggagttaagag 9660+180 . . . . . . ccagaatgtagattgctctcagattagaaaacaaacaaaaccctgagacactcattttgc 9660+240 . . . . | . . aaatagtggaatgagtcgacatatagcctttggttctttccctttctag | cccatggattt 9660+300 3220+1 | P M D F 3220+4 . | . . . . . tggaattcttccatgcacg | gtgagtctggcttcctctcactggcggccatggctgtgctc 9660+360 G I L P C T | 3220+10 . . . . . . ctggagatactggcacacctgtctccagatcagaatggtcttagctgatacttaggacac 9660+420 . . . . . . ttttgcagaagattatgaattgataggccaaacaaaatgaaaacaagcccttaatacagc 9660+480 . . . . . . aaacttagcttctcaaactgagaacatttttcgttttcttttgttttttaataagatttt 9660+540 . . . . . . atgaagtttcagtttggcgcctccattcatcactctctcttagagaacaattgtttgttt 9660+600 . . . . . . tggattgcacacaagggagatatccccagttctgatttttttttttcttgagcttaatga 9660+660 . . . . . . agacaattgaagaagggagcagaaggaattggtcttaattttgcctaaattcttcttaga 9660+720 . . tctcaaaattattacatgcctcatt 9660+745 --------------------- middle of intron --------------------- . . 9661-744 ataaaattagcttattaataaatt 9661-721 . . . . . . tgttatgtgaaatgctttatttcagttttctatatgcaaatatagaaaatgctatgcaaa 9661-661 . . . . . . taaaagcaatctatattaaaacactgatatagcaacaggttatttataaatttatttttt 9661-601 . . . . . . agatcatatatttgaatgttgtttaatagagtatgatatttttcttacggagataaacat 9661-541 . . . . . . ttatattctatattatgtgttatgtggcctgaagtaattaattttctttcaataaggggc 9661-481 . . . . . . aatctgatgaagatctgagcatttaagagggctgagcagttagttgctggtaattttttt 9661-421 . . . . . . ggcttccatgaccaaagtaggtaatttgctttagtaaccaaagtagattggtgaagatta 9661-361 . . . . . . gtaattcttctgcttaccaacttaaaccaaggtggctttccataggtgaatagaattttt 9661-301 . . . . . . ttttcttaatttatgtagaacttttgcagttcaaataagggtttttaggaattgaaactt 9661-241 . . . . . . ggtaaacattcagtggtcaagttggttgaatttccattgcattgtaggtcatcagtcaaa 9661-181 . . . . . . gagataatgaatttggaaaagttcaaaacaatcttaataaaacagtggtcaatagagttc 9661-121 . . . . . . acacatcattgagcactttactcctttatttttccttttcaaggctttattcttaactag 9661-61 . . . . . . aattctgccatctccttgtgtttttctttctaggttttctgctttgattctgcatttcag 9661-1 | 54 . . . . . . | GATGCAATCCAGGAGAAATTTTACCCACCACGTTTCATTCAAGTGCCAGAGAACATGTCG 9720 | D A I Q E K F Y P P R F I Q V P E N M S 3240
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